A Case of Cyclic Neutropenia with Special Reference to the Function of Neutrophil Mobilization
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- UYAMA Yuhko
- Department of Pediatrics, Tokushima Prefectural Hospital
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- MIZUI Mitsuo
- Department of Pediatrics, Tokushima Prefectural Hospital
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- TANAKA Hiroshi
- Department of Pediatrics, Tokushima Prefectural Hospital
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- NINOMIYA Tsuneo
- Department of Pediatrics, School of Medicine, Tokushima University
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- YAMADA Tadashi
- Department of Pediatrics, School of Medicine, Tokushima University
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- MIYAO Masuhide
- Department of Pediatrics, School of Medicine, Tokushima University
Bibliographic Information
- Other Title
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- Cyclic Neutropeniaの1例及びその白血球遊走機能について
- Cyclic Neutropenia ノ 1レイ オヨビ ソノ ハッケッキュウ
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Abstract
This report concerns with cyclic neutropenia in a 7-year-3-month-old girl, having stomatitis, furunculosis, lymphadenitis and fever up to 39°C in the interval of approximately 3 weeks since the age of 2 weeks.<br>The peripheral blood picture after admission revealed that the neutropenia recurred every 19 days and the other formed elements of the blood, monocytes, lymphocytes, eosinophils, basophils and red blood cells, also showed periodic fluctuations. During the neutropenic phase, bone marrow was hypocellular with absence of mature neutrophils and increase in neutrophilic promyelocytes. During the neutrophilic phase, bone marrow was normocellular with increase in mature neutrophils, neutrophilic myelocytes and metamyelocytes and decrease in neutrophilic promyelocytes and myeloblasts. The serum protein electrophoresis showed hypergammaglobulinemia. Bone marrow granulocyte reserves to hydrocortisone and marginal granulocyte reserves to epinephrine were tested during both neutropenic and neutrophilic phases. It was concluded that bone marrow and marginal granulocyte pool sizes were generally small during the neutropenic phase. When no netrophils were present in the peripheral blood, local inflammatory response (skin window test) was hypocellular with mononuclear cell infiltrations 10 hours after abrasion. When netrophils were normal in number, abundant neutrophilic infiltration began 2 hours after the initiation of inflammation, and neutrophilic infiltration was gradually replaced by mononuclear cell infiltration beginning after 5 hours.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 17 (12), 1309-1319, 1976
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390282680012691584
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- NII Article ID
- 130004917577
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:CSiC387lsVc%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 1910293
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- PubMed
- 1035276
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed