Humoral Immunity in Aplastic Anemia

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Other Title
  • 再生不良性貧血の液性免疫能
  • サイセイ フリョウセイ ヒンケツ ノ エキセイ メンエキノウ

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Description

Levels of each class of serum immunoglobulin were studied in 15 patients with aplastic anemia in order to clarify the immunologic capability of those patients. And the correlation between their levels and peripheral blood lymphocyte counts or degree of severity of aplastic anemia was also studied.<br>Peripheral blood lymphocyte counts with the mean of 1420±626/cmm (mean±1S. D.) were decreased below normal range. Levels of γ-globulin and Ig G were within normal range with the mean of 0.97±0.39g/dl and 1106±441 mg/dl respectively, though low levels of γ-globulin were detected in one third of patients. The mean value of IgA was within normal limits. Elevated IgM values were demonstrated with the mean of 170±78 mg/dl.<br>Peripheral blood lymphocyte counts were not significantly correlated with γ-globulin, IgG and IgA. Weak correlation was obtained between lymphocyte counts and IgM. No significant correlation was found between serum immunoglobulin values and peripheral blood B-lymphocyte counts or plasma cell counts in bone marrow. Degree of severity of aplastic anemia was not significantly correlated with peripheral blood lymphocyte counts and serum immunoglobulin levels.<br>Serial estimation of serum immunoglobulin in those patients revealed several types of change of immunoglobulin in the course of the disease…gradual increase, unchanged, increase following decrcase and decrease…but no correlation was obtained between such changes and prognosis.<br>Adrenocortical steroid caused transient decrease in serum immunoglobulin levels in about half patients, and so the patients with hypogammaglobulinemia, to whom steroid is administered, must be fully attended.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 19 (1), 15-21, 1978

    The Japanese Society of Hematology

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