A case of colchicine-responsive Mollaret’s meningitis with <i>MEFV</i> gene mutation

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Other Title
  • コルヒチンが有効なMollaret髄膜炎で，<i>MEFV</i>遺伝子変異をみとめた1例
  • 症例報告 コルヒチンが有効なMollaret髄膜炎で,MEFV遺伝子変異をみとめた1例
  • ショウレイ ホウコク コルヒチン ガ ユウコウ ナ Mollaret ズイマクエン デ,MEFV イデンシ ヘンイ オ ミトメタ 1レイ
  • A case of colchicine-responsive Mollaret’s meningitis with MEFV gene mutation

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Description

A 66-year-old woman was admitted to our hospital with recurrent meningitis. She presented with 10 episodes of meningitis in 10 months. Examination of cerebrospinal fluid demonstrated pleocytosis, with neutrophils dominant at the early stage, and lymphocytes dominant at the late stage. Mollaret cells were found and the level of IL-6 was increased in cerebrospinal fluid. Several antibiotics and antiviral agents failed to prevent relapse. However, colchicine therapy successfully prevented the recurrence of meningitis. Genetic testing for familial Mediterranean fever (FMF) showed a mutation in the MEFV gene. It is difficult to diagnose the cause of Mollaret’s meningitis in some patients. FMF, neuro-Behçet’s disease, and neuro-Sweet disease should be included in the differential diagnosis of recurrent meningitis. In addition, colchicine therapy can prevent the relapse of meningitis in such cases.

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 54 (2), 124-129, 2014

    Societas Neurologica Japonica

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