Development of AML without karyotype abnormalities including the Ph chromosome in a CML patient on second-generation TKI therapy

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  • SAKAI Toshiro
    Department of Internal Medicine, Hematology and Oncology, Asahikawa Red Cross Hospital
  • KONUMA Yuichi
    Department of Internal Medicine, Hematology and Oncology, Asahikawa Red Cross Hospital
  • SHIMOYAMA Saori
    Department of Internal Medicine, Oncology and Hematology, Sapporo Medical University School of Medicine
  • KOHDA Kyuhei
    Department of Internal Medicine, Hematology and Oncology, Asahikawa Red Cross Hospital

Bibliographic Information

Other Title
  • 第二世代チロシンキナーゼ阻害薬治療中の慢性骨髄性白血病に発症した正常核型急性骨髄性白血病
  • 症例報告 第二世代チロシンキナーゼ阻害薬治療中の慢性骨髄性白血病に発症した正常核型急性骨髄性白血病
  • ショウレイ ホウコク ダイニ セダイ チロシンキナーゼ ソガイヤク チリョウ チュウ ノ マンセイ コツズイセイ ハッケツビョウ ニ ハッショウ シタ セイジョウカクガタ キュウセイ コツズイセイ ハッケツビョウ

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Description

<p>A 58-year-old man was diagnosed with accelerated phase chronic myelogenous leukemia (CML). He was treated with dasatinib and followed-up; 6 months later, he achieved a complete molecular response. Seventeen months after this therapy, he developed pancytopenia, and was examined. His diagnosis was Ph-negative acute myeloid leukemia (AML) with no karyotype abnormalities. He was administered two courses of induction chemotherapy, and during the first remission, he received allogeneic hematopoietic stem cell transplantation. Treatment with a tyrosine kinase inhibitor (TKI) achieved a successful outcome. However, approximately 10% of CML cases develop clonal cytogenetic changes in Ph-negative cells during TKI treatment, and rarely, cases of Ph-negative myelodysplastic syndrome or AML are reported. Furthermore, similar to our case, CML patients developing AML with Ph-negative and normal chromosome abnormalities have been reported. We suggest vigilant monitoring during TKI therapy and stress the importance of further analysis based on similar accumulated cases.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (11), 2329-2333, 2016

    The Japanese Society of Hematology

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