Amyotrophic lateral sclerosis in totally locked-in state

DOI PubMed 8 References Open Access
  • Oyanagi Kiyomitsu
    Department of Brain Disease Research, Shinshu University School of Medicine
  • Mochizuki Yoko
    Department of Pathology, Tokyo Metropolitan Neurological Hospital Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled
  • Nakayama Yuki
    Laboratory of Nursing Research for Intractable Disease, Tokyo Metropolitan Institute of Medical Science
  • Hayashi Kentaro
    Department of Neurology, Tokyo Metropolitan Neurological Hospital
  • Shimizu Toshio
    Department of Neurology, Tokyo Metropolitan Neurological Hospital
  • Nagao Masahiro
    Department of Neurology, Tokyo Metropolitan Neurological Hospital
  • Hashimoto Tomoyo
    Department of Brain Disease Research, Shinshu University School of Medicine Department of Neurology, University of Occupational and Environmental Health
  • Yamazaki Mineo
    Department of Neurology, Nippon Medical University
  • Matsubara Shiro
    Department of Neurology, Tokyo Metropolitan Neurological Hospital
  • Komori Takashi
    Department of Pathology, Tokyo Metropolitan Neurological Hospital

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Other Title
  • Totally locked-in state患者の脳と脊髄における障害部位と保全部位

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Description

Seven autopsy patients with amyotrophic lateral sclerosis (ALS) in totally locked-in state (TLS) were examined neuropathologically. The patients were composed of 4 males and 3 females, and 3 with familial, 1 sporadic but with mutation in SOD1 gene, and 3 sporadic patients with unremarkable gene mutation. The brains weighed 715, 783, 1,019, 1,050, 1,170, 1,190 or 1,233 g. The tegmentum of the brain stem was markedly degenerated in every patient, and the tracts relating to the somatic sensory and auditory were involved in the lesions.

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 53 (11), 1399-1401, 2013

    Societas Neurologica Japonica

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