Successful treatment with a combination of lenalidomide and dexamethasone for cryoglobulinemia associated with multiple myeloma

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  • TANIGUCHI Hiroaki
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • IMAIZUMI Yoshitaka
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • MAKIYAMA Junya
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • ANDO Koji
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • SAWAYAMA Yasushi
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • IMANISHI Daisuke
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • TAGUCHI Jun
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • TSUSHIMA Hideki
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • HATA Tomoko
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
  • MIYAZAKI Yasushi
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University

Bibliographic Information

Other Title
  • クリオグロブリン血症に対してレナリドミド・デキサメサゾン併用療法が有効であった多発性骨髄腫
  • 症例報告 クリオグロブリン血症に対してレナリドミド・デキサメサゾン併用療法が有効であった多発性骨髄腫
  • ショウレイ ホウコク クリオグロブリン ケツショウ ニ タイシテ レナリドミド ・ デキサメサゾン ヘイヨウ リョウホウ ガ ユウコウ デ アッタ タハツセイ コツズイシュ

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Abstract

Cryoglobulinemia (Cg) in multiple myeloma (MM) is rare and no standard treatment has yet been established. Herein, we report a case of MM with Cg, successfully treated with a combination of lenalidomide and dexamethasone. A 76-year-old woman suffering from skin ulcerations, extremity pain and peripheral neuropathy was diagnosed as having IgG-kappa MM with Cg in 1992. She intermittently received conventional chemotherapy, immunosuppressant therapy and plasma exchange. Despite these treatments, Cg-related symptoms eventually became uncontrollable. She was admitted to our hospital in 2012 because of worsening skin symptoms involving both ankles. Plasmapheresis proved ineffective. Improvement of skin ulcerations and numbness was achieved with administration of lenalidomide at 25 mg daily with weekly dexamethasone, which also decreased the cryoglobulin level. The course of this patient suggests that lenalidomide plus dexamethasone is a promising treatment for MM with Cg.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 55 (8), 953-957, 2014

    The Japanese Society of Hematology

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