Prospective Study of Effect of Fluoxymesterone on Aplastic Anemia

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  • HIROTA Yutaka
    Department of Hematological Disease Center, Nagoya National Hospital

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Other Title
  • Prospective studyによる男性ホルモンFluoxymesteroneの再生不良性貧血の造血効果に対する検討
  • Prospective Study ニヨル ダンセイ ホルモン Fluoxym

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Description

A prospective study was carried out on patients with aplastic anemia to evaluate the hematopoietic effects of fluoxymesterone objectively. The attending physicians treated 41 adults, 20 males and 21 females, suffering from acquired aplastic anemia with 0.5 mg/kg/day of fluoxymesterone. The RBC, hemoglobin, WBC and platelet levels were used as clinical parameters of the effects of therapy, and GOT, GPT and virilization were used to monitor the development of any side effects.<br>Remission was seen in 43.9% of the patients after three months, and this rose to 64.0% after six months. Six months also seemed to be a reasonable period of therapy from the viewpoint of increasing the RBC and Hb levels.<br>After both three and six months of therapy, about 70% of the patients showed abnormal GOT and GPT values, while about 30% showed signs of virilization.<br>This prospective study indicates that fluoxymesterone is a valuable drug for the treatment of aplastic anemia.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 18 (11), 1318-1327, 1977

    The Japanese Society of Hematology

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