POEMS syndrome diagnosed by detection of M-protein on immunofixation and increased level of vascular endothelial growth factor

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  • HATTORI Yukako
    Department of Hematology, Japan Red Cross Shizuoka Hospital Department of Hematology, Yokohama City University Medical Center
  • TAGUCHI Jun
    Department of Hematology, Japan Red Cross Shizuoka Hospital
  • IMAI Noboru
    Department of Neurology, Japan Red Cross Shizuoka Hospital
  • WASANO Koichiro
    Department of Otolaryngology, Japan Red Cross Shizuoka Hospital
  • MATSUURA Shiro
    Department of Hematology, Japan Red Cross Shizuoka Hospital
  • KOHARAZAWA Hideyuki
    Department of Hematology, Japan Red Cross Shizuoka Hospital
  • ISHIGATSUBO Yoshiaki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • FUJISAWA Shin
    Department of Hematology, Yokohama City University Medical Center

Bibliographic Information

Other Title
  • 免疫固定法によるＭ蛋白検出とＶＥＧＦ高値で診断したＰＯＥＭＳ症候群
  • メンエキ コテイホウ ニ ヨル M タンパク ケンシュツ ト VEGF コウチ デ シンダン シタ POEMS ショウコウグン

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Abstract

A 48-year-old male with Castleman disease developed symptoms typical of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal-protein and skin changes) but M-protein was not detected by immunoelec-trophoresis. He was diagnosed as having POEMS syndrome based on IgA-λ detected by immunofixation electrophoresis and an increased level (3,170 pg/ml) of vascular endothelial growth factor (VEGF). After diagnosis, the patient underwent autologous peripheral blood stem cell transplantation safely and remained relapse-free and in good condition for 15 months. This case suggests that immunofixation electrophoresis and detection of elevated serum VEGF level are useful methods for earlier diagnosis of POEMS syndrome.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 52 (4), 219-222, 2011

    The Japanese Society of Hematology

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