Vitamin B12 Malabsorption in the Patients with Blind Loop Syndrome, a Continued Report

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  • NAKAJIMA Takashi
    The Department of Geriatric Medicine, Izu Teishin Hospital
  • ABE Tsukasa
    The Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
  • YODA Yasuhiro
    The Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
  • TANOUE Kenjiro
    The Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
  • KUDO Hideki
    The First Department of Internal Medicine, Tokyo Medical and Dental University
  • KAWADA Ken-ichi
    The First Department of Internal Medicine, Tokyo Medical and Dental University
  • NOMURA Takeo
    The First Department of Internal Medicine, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • Blind Loop SyndromeにみられたVitamin B12 malabsorptionの発生機転について（続報）
  • Blind Loop SyndromeにみられたVitamin B12 malabsorptionの発生機転について-続-
  • Blind Loop Syndrome ニ ミラレタ Vitamin B12

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Abstract

Vitamin B12 (V. B12) malabsorption was observed in a patient with a blind loop in addition to our previous report. This malabsorption was not improved during the administration of tetracycline (TC), unlike the malabsorption previously experienced in four patients with blind loop syndrome. A large number of E. coli resistant to TC was found in the stool of the patient. The administration of Kanamycin effective to E. coli together with TC was followed by improvement of V. B12 malabsorption and disappearance of the E. coli. This finding strongly suggested that the microorganisms resident in the loop were important in the pathogenesis of the V. B12 malabsorption.<br>A serial study of the patient was performed regarding V. B12 absorption test, qualitative and quantitative analysis of fecal bacteria and in vitro measurement of the bacterial uptake of V. B12. The relationship between the rate of V. B12 absorption and the nature of flora was not apparent.<br>It was surprising that the rates of the V. B12 absorption tested one year after the cessation of antibiotics were still higher than those before Kanamycin. This phenomenon may suggest some important factors in V. B12 malabsorption other than the bacterial uptake of V. B12.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 18 (11), 1312-1317, 1977

    The Japanese Society of Hematology

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