Associated tumors in patients with anti-<i>N</i>-methyl-<i>D</i>-aspartate receptor (NMDAR) encephalitis

DOI PubMed 6 References Open Access
  • Hara Makoto
    Division of Neurology, Department of Medicine, Nihon University School of Medicine
  • Morita Akihiko
    Division of Neurology, Department of Medicine, Nihon University School of Medicine
  • Kamei Satoshi
    Division of Neurology, Department of Medicine, Nihon University School of Medicine

Bibliographic Information

Other Title
  • 抗NMDA受容体脳炎における合併腫瘍について

Description

In 2007, Dalmau and colleagues described anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma. As the numbers of patients with anti-NMDAR encephalitis increased, the frequency of paraneoplastic findings declined. The frequency of anti-NMDAR encephalitis with the tumor declined to 60% of a total of 100 patients in 2008, and 42% of a total of 400 patients in 2011. This 42% was the similar value as the tumor frequency in Acute Juvenile Female Non-Herpetic Encephalitis in Japan. It was also revealed that the discrepancies in tumor frequency of anti-NMDAR encephalitis between investigations existed. The results of stratification analyses of anti-NMDAR encephalitis revealed that patients who were younger than 18 years old and male patients with anti-NMDAR encephalitis were less likely to have associated tumors. Dalmau also reported tumors other than ovarian tumors were associated with 2% (9/400) of patients in 2011. These patients included breast cancer, neuroendocrine tumors, pancreatic carcinoma, sex cord stromal tumors, testicular germ-cell tumors and small-cell lung carcinoma. We encountered a 65-year-old female affected by anti-NMDAR encephalitis with carcinosarcoma with neuroendocrine differentiation of the uterus. The prognosis of anti-NMDAR encephalitis with malignant tumor could be dependent on the prognosis of the associated tumor.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 52 (11), 979-981, 2012

    Societas Neurologica Japonica

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Details 詳細情報について

  • CRID
    1390282680013353216
  • NII Article ID
    130004505232
  • DOI
    10.5692/clinicalneurol.52.979
  • COI
    1:STN:280:DC%2BC3s7ns1yguw%3D%3D
  • ISSN
    18820654
    0009918X
  • PubMed
    23196490
  • Text Lang
    ja
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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