A case of mononeuropathy multiplex associated with idiopathic thrombocytopenic purpura

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  • Nakamura Norimichi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University
  • Shigeto Hiroshi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University
  • Isobe Noriko
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University
  • Tanaka Masato
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University
  • Ohyagi Yasumasa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University
  • Kira Jun-ichi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University

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  • 特発性血小板減少性紫斑病に関連した多発単神経障害の１例
  • トクハツセイ ケッショウバン ゲンショウセイ シハンビョウ ニ カンレン シタ タハツタンシンケイ ショウガイ ノ 1レイ

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Abstract

We report a case of mononeuropathy multiplex with idiopathic thrombocytopenic purpura (ITP). A 78-year-old man developed patches of purpura on his left forearm. His platelet count was 11,000/μl and platelet-associated IgG was elevated. He was diagnosed as having ITP. At the beginning of the following month, he noticed dysesthesia and weakness of his left finger and left lower limb, as well as dysesthesia of his bilateral lower thighs. Neurological examination revealed weakness in the area of the left ulnar nerve and of the left anterior tibial muscle. Dysesthesia presented in the area of the left ulnar nerve and bilateral superficial peroneal nerves. Nerve conduction studies revealed asymmetric axonal sensorimotor neuropathy (mononeuropathy multiplex). A cerebrospinal fluid specimen showed a normal cell count and normal protein level. Serum anti-ganglioside antibody was negative. The platelet count gradually increased after the introduction of corticosteroid therapy. His neurological deficits and electrophysiological findings also improved. Immune-mediated neuropathy was suggested as the cause of his mononeuropathy multiplex with ITP.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 50 (7), 482-484, 2010

    Societas Neurologica Japonica

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