Chromosome Abnormalities Induced by Anticancer Drugs and Radiation in Cultured Lymphocytes of Children with Acute Leukemia in Complete Remission

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  • KANEKO Yasuhiko
    Chromosome Research Unit, Faculty of Science, Hokkaido University
  • TAKEDA Takeo
    Department of Pediatrics, Hokkaido University School of Medicine

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Other Title
  • 小児急性白血病完全寛解時における，制癌剤および放射線により誘起されたリンパ球の染色体異常の検討
  • ショウニ キュウセイ ハッケツビョウ カンゼン カンカイジ ニ オケル セイガ

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Abstract

In an attempt to evaluate possible secondary carcinogenic and genetic effects of intensive chemotherapy and radiotherapy, the types and frequencies of chromosome abnormalities were investigated in cultured lymphocytes from 15 children with acute leukemia who achieved therapeutically a complete remission. For control, were provided 14 healthy adults (group A). Out of the 15 leukemic children 12 received only chemotherapy (group B), while the remaining 3 received both chemotherapy and radiotherapy of central nervous system (group C). In addition, 2 brain tumor patients who received a cranial radiotherapy were studied (group D).<br>A significantly higher incidence of chromosome abnormalities was observed in group B, C and D, as compared with group A. The aberration incidence was highest in group C, which was ascribed to the increased number of hypodiploid cells with chromosome-type structural rearrangements, probably due to the radiotherapy. In contrast, the chromosome aberrations shown in group B were mostly of chromatid type, though chromosome-type aberrations were also noted in some cases of this group. Comparing the aberration rates between group C and D, it was suggested that the cranial irradiation was less hazardous than the spino-cranial irradiations.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 17 (5), 527-533, 1976

    The Japanese Society of Hematology

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