A pregnant patient with anti-MuSK antibody positive myasthenia gravis and her infant with transient neonatal myasthenia gravis

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  • Kanzaki Akihiro
    Department of Neurology, Hiroshima City Hospital
  • Motomura Masakatsu
    Department of Clinical Neuroscience and Neurology, Graduate School of Biomedical Sciences, Nagasaki University

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Other Title
  • 抗ＭｕＳＫ抗体陽性の重症筋無力症の妊婦例と新生児一過性重症筋無力症児例
  • 症例報告 抗MuSK抗体陽性の重症筋無力症の妊婦例と新生児一過性重症筋無力症児例
  • ショウレイ ホウコク コウMuSK コウタイ ヨウセイ ノ ジュウショウキン ムリョクショウ ノ ニンプレイ ト シンセイジ イッカセイ ジュウショウキン ムリョクショウジレイ

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Abstract

A 30-year-old healthy woman experienced speech disturbance and swallowing difficulty at two months of pregnancy. She was diagnosed as myasthenia gravis (MG) with anti-MuSK antibodies. At eight months of pregnancy, bulbar palsy, eye movement disturbance, and muscle weakness worsened unexpectedly. Plasma exchange was performed three times daily starting from the 1st day of the 37th pregnancy week (2L/day, albumin substitution of 5%) and the patient underwent caesarean section and gave birth to the girl safely. The infant had anti-MuSK antibodies in the serum and umbilical cord blood. The infant's suckling power was weak. The infant was diagnosed as transient neonatal myasthenia gravis. There is no case where management of MG has been performed from the period of pregnancy for anti-MuSK positive patients. For the control of Anti-MuSK positive patients in addition to normal care for Anti-AChR antibodies positive patients, it is important to carefully observe symptoms caused by bulbar palsy, draw attentions on malnutrition and polyhydramnios, and perform simple plasmapheresis on regular basis without any delay.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 51 (3), 188-191, 2011

    Societas Neurologica Japonica

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