Granulocytopenia Associated with Anti-thyroid Drugs

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  • MATSUMOTO Noboru
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • SUETSUGU Masanobu
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • KOBAYASHI Katsumasa
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ABE Shigenobu
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • KAGEOKA Takeshi
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ARIYOSHI Kunio
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • TAJIRI Mitsuaki
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • NAKASHIMA Koji
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • SHINOHARA Kenji
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ONO Junichiro
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ODA Susumu
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ODA Etsuko
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • SHIOMURA Tadahiko
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • FUJII Hisaichi
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • HIROSHIGE Yukio
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • YAMAUCHI Katsuyo
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • MIWA Shiro
    Third Department of Internal Medicine, Yamaguchi University School of Medicine

Bibliographic Information

Other Title
  • 抗甲状腺剤による顆粒球減少症
  • コウ コウジョウセンザイ ニヨル カリュウキュウ ゲンショウショウ

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Description

The incidence of granulocytopenia in association with anti-thyroid drugs has been studied. Of 78 patients treated with methimazole for the past six years, 7 cases developed neutropenia of less than 1,000/mm3. Decrease in neutrophil count more than 2,000/mm3 comparing to the values before the therapy was noted in 20.5% of the cases during the administration of the drug. Though most of the episodes of neutropenia were transient and reversible, one case developed classical symptoms of agranulocytosis.<br>Occurrence of neutropenia induced by methimazole is related to the duration of the therapy and seems to be dose-dependent. Therefore, frequent routine blood cell counts may be necessary for the early detection of leukopenia and prevention of agranulocytosis during anti-thyroid medication.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 17 (1), 82-87, 1976

    The Japanese Society of Hematology

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