Immunopathological Study in Thymoma Patients

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  • NAKATA Yasunari
    The Second Department of Internal Medicine, Okayama University Medical School
  • KONDO Akira
    The Second Department of Internal Medicine, Okayama University Medical School
  • KATAOKA Mikio
    The Second Department of Internal Medicine, Okayama University Medical School
  • TAKASUGI Kenta
    The Second Department of Internal Medicine, Okayama University Medical School
  • MITO Toshimasa
    The Second Department of Internal Medicine, Okayama University Medical School
  • OHONOSHI Taisuke
    The Second Department of Internal Medicine, Okayama University Medical School
  • KIMURA Ikuro
    The Second Department of Internal Medicine, Okayama University Medical School

Bibliographic Information

Other Title
  • 胸腺腫患者の免疫異常の検討
  • 胸腺腫患者の免疫異常の検討--リンパ球の動態を中心として
  • キョウセンシュ カンジャ ノ メンエキ イジョウ ノ ケントウ リンパキュウ
  • —リンパ球の動態を中心として—

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Abstract

An immunopathological study of 21 patients with thymoma was perfomed. The median age was 51, with range of 26-69 years. There were 11 male and 10 female. All thymoma of this series were detected by thymectomy, biopsy and necropsy. Myasthenia gravis was present in 10 patients, including 1 patient who also had pure red cell aplasia. Sjögren's syndrome was present in 2 cases, and pure red cell aplasia in 1. Four cases were predominantly epitherial cellular type, 9 were lymphocytic and 8 were mixed. The average of circulating lymphocyte counts of the thymoma patients was 2986/cmm and was higher than normal. There was an increase in the number of non-T and non-B lymphocyte (null-lymphocyte). Both counts of T and B-lymphocytes were within normal value. The response of the peripheral lymphocyte in thymoma patients in vitro against PHA-P stimulation was significantly suppressed than healthy lymphocyte. Antinuclear antibody was found in 75% serum of thymoma patients.<br>In 9 thymoma obtained at thymectomy, the median percentage of T-lymphocyte was 72 and B-lymphocyt was 4. Sixteen patients were studied prospectively before and after thymectomy, and there was a decrease in peripheral lymphocytes after thymectomy that was statistically significant. The proportion of decreased lymphocytes after thymectomy was mainly null-lymphocytes. The thymoma patients had abnormality of humoral and cellular immunity.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 21 (2), 189-194, 1980

    The Japanese Society of Hematology

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