A Study on the Erythrocyte Membrane Fragility in Various Hematological Disorders with Coil Planet Centrifuge System

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  • MOHRI Hiroshi
    Department of Internal Medicine, Devision of Hematology, Fujigaoka Hospital, University of Showa
  • TERADA Hideo
    Department of Internal Medicine, Devision of Hematology, Fujigaoka Hospital, University of Showa

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Other Title
  • 各種血液疾患における赤血球膜抵抗の検討
  • 各種血液疾患における赤血球膜抵抗の検討--CPCを用いて
  • カクシュ ケツエキ シッカン ニ オケル セッケッキュウ マク テイコウ ノ
  • —CPCを用いて—

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Abstract

Osmotic fragility test of erythrocytes by coil planet centrifuge was studied in 33 patients of iron deficiency anemia, 9 of polycythemia vera, 8 of hemolytic anemia (hereditary spherocytosis 5, autoimmune hemolytic anemia 2, paroxysmal nocturnal hemoglobinuria 1), 7 of acute leukemia, 6 of aplastic anemia, 6 of malignant lymphoma, 3 of multiple myeloma, and 3 of SLE.<br>In 35 healthy adults, lysis of erythrocytes began at 101.4±4.8 mOsM and completed at 59.1±2.6 mOsM.<br>In iron deficiency anemia osmotic fragility was within normal range. The peak of osmotic fragility curve (HMP) was shifted to the left with improvement of anemia.<br>In hemolytic anemia osmotic fragility of erythrocytes always increased. In autoimmune hemolytic anemia the good correlation between erythrocyte osmotic fragility and reticulocyte counts. Osmotic fragility tended to be normalized when their hemolytic signs and symptoms improved.<br>In acute leukemia osmotic fragility increased in pre-treated or relapsed stage and normalized in remission.<br>In SLE marked increase in osmotic fragility was found in active stage and returned to normal in inactive stage.<br>In multiple myeloma osmotic fragility showed remarkable increase.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 21 (4), 506-512, 1980

    The Japanese Society of Hematology

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