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An autopsy case of progressive generalized muscle atrophy over 14 years due to post-polio syndrome
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- Oki Ryosuke
- Department of Clinical Neuroscience, Institute of Health Bioscience, University of Tokushima Graduate School
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- Izumi Yuishin
- Department of Clinical Neuroscience, Institute of Health Bioscience, University of Tokushima Graduate School
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- Murayama Shigeo
- Department of Neuropathology, Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology
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- Uchino Akiko
- Department of Neuropathology, Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology
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- Kaji Ryuji
- Department of Clinical Neuroscience, Institute of Health Bioscience, University of Tokushima Graduate School
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- Ogawa Hirohisa
- Department of Molecular and Environmental Pathology, Institute of Health Bioscience, University of Tokushima Graduate School
Bibliographic Information
- Other Title
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- 約14年の経過でポストポリオ症候群が広範に進行した1剖検例
- Published
- 2016
- Resource Type
- journal article
- DOI
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- 10.5692/clinicalneurol.cn-000761
- Publisher
- Societas Neurologica Japonica
Search this article
Description
We report the case of a 72-year-old man who had contracted acute paralytic poliomyelitis in his childhood. Thereafter, he had suffered from paresis involving the left lower limb, with no relapse or progression of the disease. He began noticing slowly progressive muscle weakness and atrophy in the upper and lower extremities in his 60s. At the age of 72, muscle weakness developed rapidly, and he demonstrated dyspnea on exertion and dysphagia. He died after about 14 years from the onset of muscle weakness symptoms. Autopsy findings demonstrated motoneuron loss and glial scars not only in the plaque-like lesions in the anterior horns, which were sequelae of old poliomyelitis, but also throughout the spine. No Bunina bodies, TDP-43, and ubiquitin inclusions were found. Post-polio syndrome is rarely fatal due to rapid progressive dyspnea and dysphagia. Thus, the pathological findings in the patient are considered to be related to the development of muscle weakness.
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 56 (1), 12-16, 2016
Societas Neurologica Japonica
