T315I positive promyelocytic crisis of chronic myeloid leukemia

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  • YAMAMOTO Eri
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • YAMAZAKI Etsuko
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • ISHIYAMA Yasufumi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • KOYAMA Satoshi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • ISHII Yoshimi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • HATTORI Yukako
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • NAKAJIMA Yuki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • TACHIBANA Takayoshi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • MIYAZAKI Takuya
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • HAGIHARA Maki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • TOMITA Naoto
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • ISHIGATSUBO Yoshiaki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine

Bibliographic Information

Other Title
  • T315I遺伝子変異を伴い急性前骨髄球性白血病へ急性転化した慢性骨髄性白血病
  • 症例報告 第170回日本血液学会例会:谷口修一例会長 推薦演題 T315I遺伝子変異を伴い急性前骨髄球性白血病へ急性転化した慢性骨髄性白血病
  • ショウレイ ホウコク ダイ170カイ ニホン ケツエキ ガッカイ レイカイ:タニグチ シュウイチレイ カイチョウ スイセン エンダイ T315I イデンシ ヘンイ オ トモナイ キュウセイ ゼン コツズイキュウセイ ハッケツビョウ エ キュウセイ テンカ シタ マンセイ コツズイセイ ハッケツビョウ

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Abstract

Promyelocytic crisis (PMC) of chronic myelogenous leukemia (CML) is relatively rare. We report a patient who progressed to PMC with a T315I mutation during the initial treatment with dasatinib for CML. He obtained hematological remission after combination therapy with all-trans retinoic acid and chemotherapy for PMC, and PML-RARA was not detected by FISH analysis. Arsenic trioxide (ATO) and imatinib therapy induced a second complete cytogenetic response, and PML-RARA mRNA detected by real-time quantitative RT-PCR dropped below the detection limit. Finally, allogeneic stem cell transplantation was performed. This case suggests that combination therapy with imatinib and ATO achieves favorable outcomes for PMC.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 55 (6), 692-696, 2014

    The Japanese Society of Hematology

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