Diffuse large B-cell lymphoma of the testis relapsed 16 years after achieving complete response

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  • 寛解16年後に再発した精巣原発びまん性大細胞型B細胞リンパ腫
  • 症例報告 寛解16年後に再発した精巣原発びまん性大細胞型B細胞リンパ腫
  • ショウレイ ホウコク カンカイ16ネンゴ ニ サイハツ シタ セイソウ ゲンパツビマンセイ ダイ サイボウガタ B サイボウ リンパシュ

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Abstract

Testicular lymphoma is a rare disease, accounting for 1-2% of non-Hodgkin lymphoma and 5-9% of all testicular tumors, and has a high relapse rate with a poor prognosis. We report a patient with testicular diffuse large B-cell lymphoma (DLBCL) who relapsed after being in remission for 16 years. He had undergone orchiectomy of the right testis and was diagnosed as having DLBCL (stage IAE) at 49 years of age. After 3 cycles of CHOP, he achieved a complete remission. Orchiectomy was performed because of a left testicular tumor, and he was again diagnosed with DLBCL at the age of 65. VH3-21 was detected in lymphoma cells at the times of both the first diagnosis and the relapse based on analysis of the variable region of the immunoglobulin heavy chain. Accordingly, the lymphoma cells at relapse were confirmed to be the same clone as that which had been documented at the first diagnosis.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (12), 2447-2451, 2015

    The Japanese Society of Hematology

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