Successful treatment with rituximab in two cases of IgM-monoclonal gammopathy of undetermined significance (MGUS) neuropathy

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  • KOIKE Michiaki
    Department of Hematology, Juntendo University Shizuoka Hospital
  • SUGIMOTO Keiji
    Department of Hematology, Juntendo University Shizuoka Hospital
  • TUSUI Miyuki
    Department of Hematology, Juntendo University Shizuoka Hospital
  • YAHATA Yuriko
    Department of Hematology, Juntendo University Shizuoka Hospital

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Other Title
  • リツキシマブが著効したIgM-monoclonal gammopathy of undetermined significance (MGUS)ニューロパチーの2症例
  • 症例報告 リツキシマブが著効したIgM-monoclonal gammopathy of undetermined significance (MGUS)ニューロパチーの2症例
  • ショウレイ ホウコク リツキシマブ ガ チョコウシタ IgM-monoclonal gammopathy of undetermined significance (MGUS)ニューロパチー ノ 2 ショウレイ

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Description

A 66-year-old male was hospitalized with muscle weakness and gait disturbance. Examination revealed IgM 3,407mg/dl (IgM, κ-type M protein) and he was diagnosed as having IgM-MGUS neuropathy. He suffered from paralysis of respiratory muscles and required a respirator support. Plasmapheresis and intravenous immunoglobulin were performed and he was weaned from the respirator. Rituximab given as 8 weekly infusions improved gait disturbance. A 71-year-old male was hospitalized with lumbago, numbness of lower extremities and gait disturbance. Examination revealed IgM 1,553 mg/dl (IgM, λ-type M protein) and he was diagnosed with IgM-MGUS neuropathy. Rituximab given as 8 weekly infusions improved gait disturbance. It was concluded that rituximab is a well-tolerated treatment that may be effective in some patients with IgM-MGUS neuropathy.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 53 (4), 450-454, 2012

    The Japanese Society of Hematology

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