Successful treatment with prednisolone for air-leak syndrome following interstitial pneumonia after allogeneic hematopoietic stem cell transplantation
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- HONDA Yuko
- Department of Pediatrics, University of Occupational and Environmental Health
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- MIYAJI Ryosuke
- Department of Pediatrics, University of Occupational and Environmental Health
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- MORITA Hiromi
- Department of Pediatrics, University of Occupational and Environmental Health
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- INAGAKI Jiro
- Department of Pediatrics, National Kyushu Cancer Center
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- KUSUHARA Koichi
- Department of Pediatrics, University of Occupational and Environmental Health
Bibliographic Information
- Other Title
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- 同種骨髄移植後に発症しステロイドが有効であった間質性肺炎に伴ったair-leak syndrome
- 症例報告 同種骨髄移植後に発症しステロイドが有効であった間質性肺炎に伴ったair-leak syndrome
- ショウレイ ホウコク ドウシュ コツズイ イショク ゴ ニ ハッショウ シ ステロイド ガ ユウコウ デ アッタ カンシツセイ ハイエン ニ トモナッタ air-leak syndrome
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Abstract
A 13-year-old boy with T lymphoblastic leukemia underwent allogeneic bone marrow transplantation from an HLA-matched sibling in the second remission phase. After the dose of cyclosporine (CyA) was reduced, dyspnea appeared on Day 117. CT revealed diffuse interstitial shadows on the bilateral lungs. The results of broncho-alveolar lavage suggested Pneumocystis jirovecii pneumonia. The dose of trimethoprim-sulfamethoxazole was increased, and steroid therapy was started. The symptoms transiently subsided, but exacerbated with a reduction in the steroid dose. On Day 139, mediastinal and subcutaneous emphysema appeared. We considered that non-infectious interstitial pneumonia was primarily involved in the pathogenesis for the following reasons: the boy was negative for β-D-glucan early after onset, and there was a correlation between the steroid-dose reduction and condition. The steroid dose was again increased to 80 mg and the symptoms promptly subsided. When late-onset non-infectious pulmonary complications after hematopoietic stem cell transplantation lead to air-leak syndrome, the mortality rate is very high. However, survival may be achieved by intensifying immunosuppressive therapy in the early stage.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 53 (4), 455-459, 2012
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680014086144
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- NII Article ID
- 130004501666
- 10030831156
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DC%2BC38jgsl2htg%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 023754389
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- PubMed
- 22687980
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed