Revival of old diagnostic markers in the cerebrospinal fluid for the detection of infectious meningitis
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- Sakushima Ken
- Department of Neurology, Hokkaido University Graduate School of Medicine
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- Yabe Ichiro
- Department of Neurology, Hokkaido University Graduate School of Medicine
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- Sasaki Hidenao
- Department of Neurology, Hokkaido University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 再注目される感染性髄膜炎の古典的髄液診断マーカー
- サイチュウモク サレル カンセンセイ ズイマクエン ノ コテンテキズイエキ シンダン マーカー
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Abstract
Bacterial meningitis and tubercular meningitis are still neurological emergencies characterized by severe mortality and morbidity. Recent studies of meta-analysis have shown the usefulness of cerebrospinal fluid (CSF) lactate and CSF adenosine deaminase (ADA) as markers for the detection of bacterial meningitis and tubercular meningitis, respectively. CSF lactate has a high sensitivity and specificity for the diagnosis of bacterial meningitis, but the sensitivity can be reduced by antibiotic pretreatment. CSF-ADA has a moderate sensitivity but a high specificity and is reliable for the diagnosis of tubercular meningitis. These old diagnostic markers can be evaluated in resource-poor settings including small general hospitals and non-specialized hospitals for infectious diseases, and they can contribute to the quick and accurate diagnosis of infectious meningitis.<br>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 52 (1), 6-11, 2012
Societas Neurologica Japonica
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Details 詳細情報について
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- CRID
- 1390282680014155136
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- NII Article ID
- 130004505026
- 40019173892
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- NII Book ID
- AN00253207
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- ISSN
- 18820654
- 0009918X
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- NDL BIB ID
- 023460000
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed