A case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation

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  • Inose Yuri
    Department of Neurology, Tokyo Women's Medical University, School of Medicine
  • Akiyama Shigeo
    Department of Neurology, Tokyo Women's Medical University, School of Medicine
  • Mochizuki Atsuko
    Department of Neurology, Tokyo Women's Medical University, School of Medicine
  • Shimizu Yuko
    Department of Neurology, Tokyo Women's Medical University, School of Medicine
  • Iwata Makoto
    Department of Neurology, Tokyo Women's Medical University, School of Medicine
  • Uchiyama Shinichiro
    Department of Neurology, Tokyo Women's Medical University, School of Medicine

Bibliographic Information

Other Title
  • 生体腎移植後にＨＴＬＶ‐１関連脊髄症を発症した１例
  • 症例報告 生体腎移植後にHTLV-1関連脊髄症を発症した1例
  • ショウレイ ホウコク セイタイジンイショク ゴ ニ HTLV 1 カンレン セキズイショウ オ ハッショウ シタ 1レイ
  • Case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation [in Japanese]

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Abstract

We report a 51-year-old man with human T lymphotropic virus type-1 (HTLV-1) associated myelopathy (HAM) manifested 10 months after renal transplantation. He had progressive spastic paralysis and neurogenic bladder for 10 years.<br> HTLV-1 antibody are positive both serum and cerebral spinal fluid (CSF).<br> Althoght HTLV-1 was not examined in the donor, it was suspected that the patient was infected by renal transplantation. After treatment of interferon-α (IFN-α), his motor function had improved and neopterin in CSF was decreased from 158pmol/ml to 89pmol/ml.<br> This is a rare case of HAM after living renal transplantation. Cyclosporin and methylpredonisolone are used as immunosuppressants for preventing graft rejection. Time for developing HAM after renal transplantation was shorter than patients after cadaveric renal transplantation.<br> More investigations are needed to clarify the mechanisms in the development of HAM associated with renal transplantation.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 50 (4), 241-245, 2010

    Societas Neurologica Japonica

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