An Essential Difference between Stroke-prone SHR (SHRSP) and Stroke-resistant SHR (SHRSR)

DOI Web Site PubMed Open Access
  • HORIE Ryoichi
    Japan Stroke Prevention Center Department of Neurosurgery Faculty of Medicine, Kyoto University
  • YAMORI Yukio
    Japan Stroke Prevention Center Department of Pathology, Shimane National Medical School
  • HANDA Hajime
    Japan Stroke Prevention Center Department of Neurosurgery Faculty of Medicine, Kyoto University

Bibliographic Information

Other Title
  • Quantitative Evidence Obtained by Yamori's Preparation II

Search this article

Description

The susceptibility to cerebrovascular fat deposition in prehypertensive SHRSP and SHRSR, with or without unilateral carotid artery ligation, was investigated.<br>Although no fat deposits were observed in either SHRSP or SHRSR without the carotid ligation, the operated group of SHRSP revealed a significantly higher susceptibility to cerebrovascular fat deposition than the operated SHRSR, qualitatively and quantitatively.<br>Cerebrovascular fat deposition was regarded as a good indicator for the detection of increased cerebrovascular permeability based on many experimental facts (Yamori et al: Jap Circulat J 39: 601, 1975). Thus, the higher susceptibility to cerebrovascular atherogenesis in prehypertensive SHRSP in comparison with SHRSR suggested that cerebrovascular wall of SHRSP had generically a greater susceptibility to vascular permeability which causes arterionecrosis followed by cerebral breeding or cerebral infarction.<br>The present study first substantiated a genetical difference, i.e., qualitative and quantitative in vulnerability to cerebrovascular permeability, apart from the heredity of severe hypertension in SHRSP. In addition, the result also suggested the osmotic fragility of erythrocyte membrane might be related to this vulnerability of cerebral arteries and a promising and practical approach for the prescience of cerebrovascular diseases.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top