Analysis of the Heart Antigens

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  • FUKUTA Shinji
    Department of Internal Medicine, Yamaguchi University School of Medicine
  • YAMAMOTO Toru
    Department of Internal Medicine, Yamaguchi University School of Medicine
  • KIMURA Yoshio
    Department of Internal Medicine, Yamaguchi University School of Medicine
  • IWAMOTO Setsuko
    Department of Internal Medicine, Yamaguchi University School of Medicine
  • MISE Junichi
    Department of Internal Medicine, Yamaguchi University School of Medicine

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Other Title
  • Analysis of the Heart Antigens--Homologous and Heterologous Anti-Heart Antibodies and Analysis of the Heart Specific Antigens
  • Analysis of the Heart Antigens Homologo
  • Homologous and Heterologous Anti-Heart Antibodies and Analysis of the Heart Specific Antigens

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Abstract

The present study has indicated the presence of 3 heart specific antigens, using homologous and heterologous antibodies produced in immunized rabbits. Two of these antigenic proteins exhibit restricted organ specificity for heart and the other one shares by heart and kidney. One of these 2 heart specific antigens reacts to both homologous and hetero-logous anti-heart sera absorbed with kidney, while the other reacts to only heterologous anti-heart sera. The former has an electrophoretic mobility corresponding to that of serum β-globulin, and is found to have a molecular weight of about 175, 000. The latter has the same electrophoretic mobility as that of α2-globulin and is found to have a molecular weight of about 50, 000.

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