Changes in Hemodynamics and Bradykinin Concentration in Coronary Sinus Blood in Experimental Coronary Artery Occlusion
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- HASHIMOTO Keiichi
- he First Department of Internal Medicine, Nippon Medical School
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- HIROSE Masaru
- he First Department of Internal Medicine, Nippon Medical School
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- FURUKAWA Soichi
- he First Department of Internal Medicine, Nippon Medical School
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- HAYAKAWA Hirokazu
- he First Department of Internal Medicine, Nippon Medical School
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- KIMURA Eiichi
- he First Department of Internal Medicine, Nippon Medical School
書誌事項
- タイトル別名
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- Changes in Hemodynamics and Bradykinin
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抄録
The following parameters were studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs: bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular max dp/dt (LV max dp/dt), and an index of myocardial contractility (LV max dp/dt/IP).<br>BK levels increased, reaching a maximum of 30±13ng/ml 2 min after coronary ligation, accompanied by a significant elevation of LVEDP, and lowering of the myocardial contractility index. HR and LV max dp/dt showed no significant changes. A positive correlation obtained between the level of BK and LVEDP, as well as a negative correlation be-tween the level of BK and of both LVSP and myocardial contractility in-dex. Pretreatment with aprotinine (Trasylol), an inhibitor of kinin forming enzyme, prevented the increase in both BK and LVEDP after coronary artery ligation and caused an elevation of myocardial contractility index. These results suggest that BK formed within ischemic myocardium exerts a negative inotropic action on the heart.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 18 (5), 679-689, 1977
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282680015565568
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- NII論文ID
- 130000762875
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- NII書誌ID
- AA00690786
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- COI
- 1:CAS:528:DyaE1cXksFOru7k%3D
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 1912911
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- PubMed
- 303709
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可