Abnormality in Catecholamine Metabolism in the Brain of Spontaneously Hypertensive Rats (SHR)

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  • Nagatsu Toshiharu
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
  • Ikeda Masato
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
  • Hirata Yoko
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
  • Fujita Keisuke
    Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University
  • Takahashi Hisahide
    Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University
  • Shinzato Masanori
    Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University
  • Yagyu Shigeru
    Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University

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  • Analysis by In Vivo Voltammetry

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The abnormality in catecholamine metabolism in the brain of SHR has been examined by use of in vivo voltammetry technique. In vivo release of dopamine and serotonin in the striatum under acute stress was more prominent in SHR at 4 weeks of age than in normotensive Wistar-Kyoto rats (WKY). Acute activation after stress of in vitro tyrosine hydroxylase activity was observed only in SHR, but tryptophan hydroxylase activity did not change significantly. It is concluded that central monoaminergic neurons are more susceptible to stress in SHR than those in WKY.

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