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- KATAGIRI Takashi
- Third Department of Internal Medicine, Showa University School of Medicine
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- KOBAYASHI Youichi
- Third Department of Internal Medicine, Showa University School of Medicine
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- SASAI Yasufumi
- Third Department of Internal Medicine, Showa University School of Medicine
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- TOBA Kenji
- Third Department of Internal Medicine, Showa University School of Medicine
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- NIITANI Hirokazu
- Third Department of Internal Medicine, Showa University School of Medicine
書誌事項
- タイトル別名
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- Alterations in Cardiac Troponin Subunit
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抄録
1. Alterations in troponin subunits in myocardial infarction were studied in the dog heart by the analysis of troponin-tropomyosin complex, i.e. native tropomyoin, of total structural proteins in SDS gel electrophoresis, and by the measurement of degree of activation of actomyosinATPase by Ca++.<br>2. At 12 to 24 hours after coronary ligation, reductions in TN-C and tropomyosin were observed followed by a decrease in TN-I at 48 hours. The relative contents of these subunits were the lowest at 72 hours to 7 days falling to less than 10% of those in the non-ischemic myocardium. On the contrary, TN-T was preserved through the course of myocardial infarction.<br>3. Actomyosin-ATPase activity was increased at 12 to 24 hours after coronary ligation and then reduced rapidly at 24 to 48 hours together with the degradation of myosin. However, the activation of actomyosin-ATPase by Ca++-troponin-tropomyosin was reduced already at 12 hours simultaneously with the reduction in TN-C, and almost completely lost at 48 hours.<br>4. Troponin subunits and actomyosin-ATPase activity returned to those of the control myocardium at 28 days after coronary ligation indicating the recovery of infarcted tissue
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 22 (4), 653-664, 1981
International Heart Journal刊行会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282680016001920
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- NII論文ID
- 130000763774
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2354932
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- PubMed
- 6457921
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可