Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
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- CHIBA Shigetoshi
- Department of Pharmacology, Shinshu University School of Medicine
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- FURUKAWA Yasuyuki
- Department of Pharmacology, Shinshu University School of Medicine
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- WATANABE Hidehiko
- Department of Pharmacology, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- Chronotropic and Inotropic Effects of 3
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Abstract
Using the isolated and blood-perfused dog atrial preparation, chronotropic and inotropic responses to 3 kinds of alpha-adrenergic blockers, phentolamine, phenoxybenzamine, and E-643, were compared.<br>When phenoxybenzamine was administered into the cannulated sinus node artery, positive chronotropic and inotropic responses were induced in doses of 10-300μg. Phentolamine also produced positive responses, but at larger doses such as 100 and 300μg, accompanying initial negative responses.<br>E-643 usually produced only negative chronotropic and inotropic effects. Positive responses to phenoxybenzamine and phentolamine were significantly suppressed by propranolol, and negative responses to E-643 and phentolamine were not modified by atropine treatment.<br>From these results and previous reports, it is assumed that sinus tachycardia induced by alpha-blockers in situ may be due to 3 different mechanisms, i.e., 1) reflex tachycardia induced by the hypotension, 2) augmented catecholamine release mediated by the block of the presynaptic alpha-adrenoceptors, and 3) direct catecholamine release from locally innervated sympathetic nerve terminals
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 22 (4), 637-641, 1981
International Heart Journal Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282680016078720
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- NII Article ID
- 130000763772
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- NII Book ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 2354928
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- PubMed
- 6117668
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed