Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients.
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- AOKI Kyuzo
- Second Department of Medicine, Nagoya City University Medical School
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- KONDO Shuta
- Second Department of Medicine, Nagoya City University Medical School
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- SATO Koichi
- Second Department of Medicine, Nagoya City University Medical School
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- KATO Kazuaki
- Second Department of Medicine, Nagoya City University Medical School
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- KAWAGUCHI Yoshinori
- Second Department of Medicine, Nagoya City University Medical School
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- MOCHIZUKI Akihiro
- Second Department of Medicine, Nagoya City University Medical School
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- YAMAMOTO Masahiko
- Second Department of Medicine, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- Hypotensive Action of Nifedipine Ca2 +
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Abstract
The hypotensive effect of nifedipine (a Cal2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol.<br>Nifedipine (10mg, sublingually) decreased blood pressure from 174/102 to 136/82mmHg with increase in heart rate and plasma renin activity. The combination of nifedipine (10mg, sublingually) and propranolol (0.2mg/Kg body weight, intravenously) decreased blood pressure from 168/104 to 131/86mmHg with decrease in heart rate and plasma renin activity.<br>Twenty-five hypertensive patients were treated with nifedipine and propranolol (10mg×3 to 4/day) together with or without diuretic for long-term. With the combination therapy, blood pressure of Group I (11 hypertensive patients with coronary heart disease) fell from 211/129 to 140/85mmHg, blood pressure of Group II (9 severe hypertensive patients without coronary heart disease) from 230/137 to 139/84mmHg, and blood pressure of Group III (5 established hypertension) from 182/107 to 134/83mmHg. With this treatment regimen, heart rate and plasma renin activity decreased, and abnormal electrocardiographic findings, hypertensive retinopathy, and renal dysfunction were improved.<br>Nifedipine, in combination with propranolol and a diuretic, is considered an effective treatment of hypertension either with or without coronary heart disease
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 22 (4), 575-584, 1981
International Heart Journal Association
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Details 詳細情報について
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- CRID
- 1390282680016081280
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- NII Article ID
- 130000763766
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- NII Book ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 2354931
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- PubMed
- 7300028
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed