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Effects of Pilsicainide on the Atrial Fibrillation Threshold in Guinea Kg Atria. A Comparative Study with Disopyramide, Lidocaine and Flecainide.
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- INOUE Miho
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- INOUE Daisuke
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- ISHIBASHI Kazuya
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- SAKAI Ryuta
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- OMORI Itsuki
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- YAMAHARA Yasuhiro
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- ASAYAMA Jun
- Second Department of Medicine, Kyoto Prefectural University of Medicine
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- NAKAGAWA Masao
- Second Department of Medicine, Kyoto Prefectural University of Medicine
Bibliographic Information
- Other Title
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- A Comparative Study with Disopyramide, Lidocaine and Flecainide
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Description
The effects of pilsicainide, a new class Ic antiarrhythmic agent, on the atrial fibrillation threshold (AFT), the atrial effective refractory period (ERP), and the interatrial conduction time (ACT) in Langendorff-perfused guinea pig hearts were investigated. These effects were compared with those of disopyramide, lidocaine and flecainide. Whole guinea pig heart was perfused with Tyrode's solution containing acetylcholine (3×10-7M). Three indices were measured before and after the administration of the test drugs using right atrial extrastimulus and high frequency stimulation. Pilsicainide, disopyramide and flecainide (≥10-6M) all significantly increased the AFT. Both pilsicainide and flecainide (≥3×10-6M) significantly prolonged the ERP, but this prolongation was less pronounced than that observed with disopyramide. The ACT was significantly prolonged with pilsicainide (≥10-6M), and this prolongation was greater than that observed with disopyramide but less than that with flecainide. Lidocaine had no effects on any of the indices measured. In conclusion, pilsicainide had a preventive effect on the atrial fibrillation induced by a combination of acetylcholine and high frequency stimulation in guinea pig hearts, by increasing the atrial ERP and slowing the interatrial conduction. These effects may explain, in part, the clinical effectiveness of this drug on paroxysmal atrial fibrillation.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 34 (3), 301-312, 1993
International Heart Journal Association