Central Modulation of Baroreceptor Reflex by Angiotensin

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  • FUKIYAMA Koshiro
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

書誌事項

公開日
1973
資源種別
journal article
DOI
  • 10.1536/ihj.14.135
公開者
International Heart Journal刊行会

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説明

A small amount of angiotensin not to cause a significant elevation of systemic arterial pressure was infused into vertebral arteries of dogs anesthetized with morphine and α-chloralose. Electrical stimulation of carotid sinus nerve caused a smaller reduction in arterial pressure and heart rate during the period of angiotensin infusion than the control period. Arterial pressure response to occlusion of the common carotid artery was not affected by the infusion of angiotensin. The results suggest that angiotensin may sensitize medullary vasomotor centre in a manner of suppressing the tonic inhibition of baroreceptor reflex, resulting in an increase of central sympathetic vasomotor outflow.

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