Constant Infusion of Hypertonic Saline in the Dog II

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  • KINOUCHI Takashi
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • NAKAMURA Kazumichi
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • ITO Teizo
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • NAGASAKA Masahito
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • TAKAHASHI Masao
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • ARAKI Yoshitaka
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • YOSHITOSHI Yawara
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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Other Title
  • Constant infusion of hypertonic saline in the dog-2-Compartmental analysis with radioactive sodium
  • Compartmental Analysis with Radioactive Sodium

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A kinetic study with Na24 was made to determine the changes in various compartments after infusion of hypertonic saline. The main change caused by the hypertonic saline loading is the expansion of the functional extracellular space. The relatively slowly exchanging pools including the intracellular space did not appear to change significantly. This is in accord with the previous result of simulation study that the increase in intracellular sodium concentration was small after hypertonic saline loading in the two-compartments model. It is concluded that the kinetics of hypertonic saline loading can be well approximated by a single capacitive system.

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