Hypotensive and Vascular Effects of Labetalol in the Normotensive Rat and Dog
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- HASHIMOTO Keitaro
- Department of Pharmacology, Niigata University School of Medicine
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- HASHIMOTO Toyozo
- Department of Pharmacology, Niigata University School of Medicine
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- IIZUKA Hiromi
- Department of Pharmacology, Niigata University School of Medicine
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- TSUKADA Tokumasa
- Department of Pharmacology, Niigata University School of Medicine
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- MATSUDA Hiroto
- Department of Pharmacology, Niigata University School of Medicine
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- IMAI Shoichi
- Department of Pharmacology, Niigata University School of Medicine
書誌事項
- タイトル別名
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- Hypotensive and Vascular Effects of Lab
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抄録
A new antihypertensive agent, labetalol, has potent hypotensive effects in the anesthetized rat and dog when given intravenously and also in the unanesthetized beagle when given orally. Labetalol slightly increased renal blood flow of the anesthetized dog while decreasing blood pressure. Labetalol slightly increased blood flow of canine femoral artery under constant pressure perfusion. However as compared with hydralazine, labetalol seems to have no marked vasodilatatory effect which accounts for its hypotensive effect.<br>Pharmacologically, labetalol possessed both α- and β-blocking activities, though weaker than phentolamine and propranolol respectively. Another specific action of labetalol was that it has stronger β-blocking action on β1 receptor (heart rate response) than on β2 receptor (blood pressure response). Like several other β-blockers, Labetalol seems to block neuronal uptake of noradrenaline.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 19 (5), 762-774, 1978
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282680017137024
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- NII論文ID
- 130000762450
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- NII書誌ID
- AA00690786
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- COI
- 1:CAS:528:DyaE1MXltVaisLw%3D
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2073439
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- PubMed
- 32409
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可