Canine X-linked muscular dystrophy in Japan (CXMD<sub>J</sub>)
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- SHIMATSU Yoshiki
- Chugai Research Institute for Medical Science, Inc.
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- KATAGIRI Kouichi
- Chugai Research Institute for Medical Science, Inc.
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- FURUTA Toshio
- Chugai Research Institute for Medical Science, Inc.
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- NAKURA Masao
- Chugai Research Institute for Medical Science, Inc.
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- TANIOKA Yoshikuni
- Central Institute for Experimental Animals
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- YUASA Katsutoshi
- National Institute of Neuroscience, National Center of Neurology and Psychiatry
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- TOMOHIRO Masayuki
- National Institute of Neuroscience, National Center of Neurology and Psychiatry
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- KORNEGAY Joe N.
- Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia
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- NONAKA Ikuya
- National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
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- TAKEDA Shin'ichi
- National Institute of Neuroscience, National Center of Neurology and Psychiatry
書誌事項
- タイトル別名
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- Canine X-Linked Muscular Dystrophy in Japan (CXMDJ).
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説明
The purpose of this study was to develop a strain of canine X-linked muscular dystrophy (CXMD), a model of Duchenne muscular dystrophy, in Japan. A female beagle was artificially inseminated with frozen-thawed spermatozoa derived from an affected golden retriever. Subsequently, two carrier female dogs (G1 carriers) and four normal male littermates were produced. Thereafter, the two G1 carriers were mated with beagle sires. As a result, each bitch whelped three times, and out of 54 pups, 17 affected male descendants, and 11 carrier female descendants (G2 carriers) were detected. One G2 carrier was then mated with a beagle sire and 15 pups in two whelpings were produced, including five affected males and four carrier females (G3 carriers). A total of 10 female beagles were artificially inseminated to evaluate the fertility of the frozen-thawed spermatozoa from the two affected dogs. The whelping rates of the two affected dogs were 4/5 and the litter sizes were 5.0 ± 1.41 and 6.0 ± 0.82, respectively. These results indicate that a canine X-linked muscular dystrophy colony has been established in Japan. We called them CXMDJ.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 52 (2), 93-97, 2003
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390282680017495552
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- NII論文ID
- 130000068464
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 6507748
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- PubMed
- 12806883
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可