Control Mechanisms of Intrasinusoidal Flow Pattern of Blood

DOI Web Site PubMed
  • 中井 正継
    Division of Instrumentation Engineering, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
  • 田村 俊世
    Division of Instrumentation Engineering, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
  • 神谷 瞭
    Division of Instrumentation Engineering, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
  • 戸川 達男
    Division of Instrumentation Engineering, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

書誌事項

タイトル別名
  • Control Mechanisms of Intrasinusoidal F

この論文をさがす

抄録

The intrasinusoidal flow pattern of blood drained from the hepatic arterial and portal venous routes was studied with and without stimulation of the hepatic nerves. This flow pattern was evaluated in terms of a relationship between hepatic arterial flow fraction of total flow and its transit time volume fraction of total blood volume of the liver. The transit time volume of the hepatic artery is defined by the product of flow and mean transit time through the hepatic arterial system. These fractions were determined by adopting a recently proposed principle of the indicator dilution technique-a double injection-single sampling site method. The hepatic arterial flow fraction in dog liver was adjusted at various levels by perfusing the hepatic artery with the animal's own blood drained from the femoral arteries. The resulting relationships between these two fractions showed linearity and a close resemblance to a line of identity over a wide range of the flow fraction both with or without stimulation. Two possible patterns of the blood flow in the sinusoids were discussed for an evaluation of these results. First, intrasinusoidal mixing of both arterial and portal blood occurs in each sinusoid at any hepatic arterial flow fraction. Second, an increase in the hepatic arterial flow fraction may give rise to functionally, not anatomically, separate sinusoids only for arterial blood. The difference between the relationships with and without nerve stimulation was statistically insignificant. This evidence implies that there is no detectable effect of the hepatic nerves on the adjustment of the intrasinusoidal flow pattern of blood.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ