Histological Analysis of Murine Colitis Induced by Dextran Sulfate Sodium of Different Molecular Weights.
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- KITAJIMA Shuji
- Center for Laboratory Animals, Saga Medical School
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- TAKUMA Shigenobu
- Center for Laboratory Animals, Saga Medical School
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- MORIMOTO Masatoshi
- Center for Laboratory Animals, Saga Medical School
Bibliographic Information
- Other Title
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- Histological analysis of murine colitis induced by dextran sulfate sodium of different molecular weight
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Abstract
In this study, we examined the relationship between the molecular weight of dextran sulfate sodium (DSS) and the features of colitis in a DSS-induced mouse model of human ulcerative colitis. DSS at three different molecular weights, 5 kD, 40 kD and 500 kD, was used in this study. DSS was administered in drinking water at 5% (w/v) to 6-7-week-old female BALB/c mice. After 7 days of treatment with DSS, the large intestine was examined histopathologically. Colitis was characterized by a loss of crypts, infiltration of inflammatory cells into the mucosa and submucosa, edema of the submucosa, erosion and ulceration and was observed in mice given the 5 kD and 40 kD forms but not the 500 kD. In the 5 kD group, colitis was observed predominantly in the cecum and upper colon. Colitis in the 40 kD group was more severe than that in the 5 kD group, and in the 40 kD group it was more severe in the lower colon than in the upper colon. These findings suggest the molecular weight of DSS to be an important factor in the murine model of colitis.<br>
Journal
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- Experimental Animals
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Experimental Animals 49 (1), 9-15, 2000
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1390282680017679104
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- NII Article ID
- 10007343130
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- NII Book ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD3cXhvVent7g%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 4960240
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- PubMed
- 10803356
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed