Determination of Serum C-Reactive Protein (CRP) in Healthy Beagle Dogs of Various Ages and Pregnant Beagle Dogs

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  • KURIBAYASHI Takashi
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University
  • SHIMADA Tokihiro
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University
  • MATSUMOTO Mariko
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University
  • KAWATO Katsuhito
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University
  • HONJYO Toshio
    Seminar on Environment, College of Environmental and Health Sciences, Azabu University
  • FUKUYAMA Masafumi
    Laboratory of Microbiology, College of Environmental and Health Sciences, Azabu University
  • YAMAMOTO Yutaka
    Farm Animal Clinic and Research Center Inc.
  • YAMAMOTO Shizuo
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University

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Description

Serum C-reactive protein (CRP) concentrations in healthy beagle dogs of various ages and in pregnant beagles were measured by enzyme-linked immunosorbent assay (ELISA). Serum CRP concentrations were 1.5-16.0 μg/ml (mean 7.9 ± 3.4 μg/ml) in male, and 1.8-18.9 μg/ml (mean 8.3 ± 4.0 μg/ml) in female dogs. No significant sex-related differences were observed in the values. Further, there were no significant age-related differences either. Serum CRP concentrations increased during pregnancy. The concentration of serum CRP in pregnant dogs peaked at 70.2-90.4 μg/ml (mean 77.5 ± 7.1 μg/ml) 30 or 45 days after ovulation, demonstrating two characteristic features of CRP concentration change in pregnant dogs.<br>

Journal

  • Experimental Animals

    Experimental Animals 52 (5), 387-390, 2003

    Japanese Association for Laboratory Animal Science

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