Relation between Stable Glycated Hemoglobin A1c and Plasma Glucose Levels in Diabetes-model Mice.

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  • DAN Katsuaki
    Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University
  • FUJITA Haruhisa
    Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University
  • SETO Yoshiko
    Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University
  • KATO Ryuichi
    Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

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タイトル別名
  • Relation between Stable Glycated Hemogl

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In an IDDM model mouse which was inoculated with a diabetogenic variant, DK-27, of encephalomyocarditis (EMC) virus, the relation between a stable glycated hemoglobin A1c (St-HbA1c) level and plasma glucose level (PGL) in the progress of diabetes was studied. The St-HbA1c level and PGL were examined every 2 weeks for 10 weeks in normal male DBA/2 and IDDM-onset mice. PGLs of normal control mice did not change, but their St-HbA1c levels were slightly increased by 0.52 to 1.03%. On the other hand, in IDDM mice, their PGLs were greatly increased (>400 mg/dl) and hyperglycemia was maintained throughout this observation period, with their St-HbA 1c noticeably increased to 3.8% according to the progress of diabetes for 10 weeks. A highly significant correlation between St-HbA1c levels and averaged PGLs for the past weeks was found in IDDM mice. To examine the reflection of St-HbA1c levels to delicately varied PGLs, we also estimated both values in IDDM mice which were treated with insulin at a minimal effective dose once a day for 4 weeks. The St-HbA1c levels in insulin-injected IDDM mice were significantly lower than those in control IDDM mice. These findings suggest that the estimation of the St-HbA1c level is useful in following up blood glucose control in a long-term therapeutical study with small laboratory animals.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 46 (2), 135-140, 1997

    公益社団法人 日本実験動物学会

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