The Production of Arthritis in Beagles by an Immunological Reaction to Bovine Serum Albumin.

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  • OHASHI Fumihito
    Departments of Veterinary Surgery, College of Agriculture, Osaka Prefecture University
  • SHIMADA Terumasa
    Veterinary Teaching Hospital, College of Agriculture, Osaka Prefecture University
  • SAKURAI Masahiko
    Departments of Veterinary Surgery, College of Agriculture, Osaka Prefecture University
  • ISHIHARA Seiko
    Departments of Veterinary Surgery, College of Agriculture, Osaka Prefecture University
  • KUWAMURA Mitsuru
    Veterinary Pathology, College of Agriculture, Osaka Prefecture University
  • YAMATE Joji
    Veterinary Pathology, College of Agriculture, Osaka Prefecture University
  • OTA Mituaki
    Veterinary Physiology, College of Agriculture, Osaka Prefecture University

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  • Production of Arthritis in Beagles by a

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Description

Arthritis was produced in beagles by the immunological reaction to bovine serum albumin (BSA). Dogs immunized with BSA showed the development of delayed type-hypersensitivity response to BSA and the significant increase in the titer of serum anti-BSA antibodies. The development of arthritis and the increase in a number of nucleated cells in synovial fluid were observed by the injection with BSA into the knee joints of immunized dogs. The synovial membrane of BSA-injected joints revealed a remarkable villous hyperplasia of membrane, and an infiltration of lymphocytes and plasma cells around vessels, resulting in a lymphoid nodule-like formation. The depositions of IgG and C3 on the surface of the synovial membrane were also observed in BSA-injected joints. Histopathological and immunopathological findings indicated that the immune response to BSA in the knee joints could induce a rheumatoid arthritis like chronic synovitis in dogs.<br>

Journal

  • Experimental Animals

    Experimental Animals 45 (4), 299-307, 1996

    Japanese Association for Laboratory Animal Science

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