Characterization of Hyperinsulinemic Recombinant Inbred(RI)Strains(SMXA-5 and SMXA-9)Derived from Normoinsulinemic SM/J and A/J Mice

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  • ANUNCIADO Rea Victoria P.
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University Department of Basic Veterinary Sciences, College of Veterinary Medicine, University of the Philippines at Los Baños, College
  • HORIO Fumihiko
    Division of Biomodelling, Graduate School of Bioagricultural Sciences, Nagoya University
  • OHNO Tamio
    Department of Parasitology, Hamamatsu University School of Medicine Institute for Laboratory Animal Research, Nagoya University School of Medicine
  • TANAKA Shin
    National Institute for Longevity Sciences, National Chubu Hospital
  • NISHIMURA Masahiko
    Institute for Laboratory Animal Research, Nagoya University School of Medicine
  • NAMIKAWA Takao
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

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タイトル別名
  • Characterizaton of Hyperinsulinemic Recombinant Inbred(RI) Strains(SMXA-5 and SMXA-9) Derived from Normoinsulinemic SM/J and A/J Mice.

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抄録

We discovered two mouse strains (SMXA-5 and SMXA-9) with hyperinsulinemia among the substrains and progenitor strains (SM/J and A/J) of the SMXA recombinant inbred (RI) strains, and characterized the two strains at 20 weeks of age. SMXA-5 (mean ± S.E.M: 9.6 ± 1.7 ng/ml) and SMXA-9 (7.7 ± 1.3 ng/ml) males had higher serum immunoreactive insulin levels than SM/J (1.4 ± 0.3 ng/ml) and A/J (1.1 ± 0.1 ng/ml) males in the nonfasting condition. The hypoglycemic response to insulin at 30 min after injection was significantly less in SMXA-5 males than in SM/J mice. Glucose tolerance test revealed that the incidence of impaired glucose tolerant males was 58% (11/19) in SMXA-5 and 42% (10/24) in SMXA-9 strains, but none in SM/J and A/J strains. SMXA-5 (209 ± 29 mg/dl) and SMXA-9 (235 ± 31 mg/dl) had higher serum triglyceride levels than SM/J (126 ± 14 mg/dl) and A/J (89 ± 5 mg/dl) males in the nonfasting condition. Histologic examination revealed enlarged islets in the pancreas of hyperinsulinemic SMXA-5 male mice. Moreover, SMXA-5 and SMXA-9 mice exhibited mild obesity. SMXA-5 and SMXA-9 males were therefore characterized by hyperinsulinemia, impaired glucose tolerance, hypertriglyceridemia and mild obesity which resembled some of the phenotypes of human Syndrome X, although both progenitor strains were normal so far as we examined. Since the RI strains are a powerful tool to facilitate polygenic-trait analysis, SMXA-5 and SMXA-9 mice will be useful materials to investigate the genetic basis of complex diseases, and are possible new metabolic models in relation to hyperinsulinemia.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 49 (2), 83-90, 2000

    公益社団法人 日本実験動物学会

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