Changes in Nasal Cavity Volume and Target Area of Exposure to Nasal Drops with Age in Rats.

DOI Web Site Web Site PubMed 3 Citations 36 References
  • KUBOYAMA Yasumasa
    Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
  • MORI Kaoru
    Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
  • SUZUKI Kazuo
    Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
  • ISHII Akio
    Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
  • SHUTO Katsuichi
    Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.

Bibliographic Information

Other Title
  • Changes in Nasal Cavity Volume and Targ

Search this article

Abstract

The changes in the nasal cavity volume of rats with age and the area exposed to nasal drops administered into the nasal cavity were investigated. Results indicated that the nasal cavity volume lineally increased as rats grew older. In 7-week-old rats, the exposed area in the case of an administration volume of 25 μl, based on practice, was naso-, maxillo-, and ethmoid turbinate and this volume was enough to expose the whole area of the nasal cavity including the ethmoid turbinate. On the other hand, in 27-week-old rats, administration volumes of 10 and 25 μl were not enough to expose the ethmoid turbinate. This indicated that the exposed area tended to become narrower in 27-week-old rats than in 7-week-old rats, but the exposed area in the case of an administration volume of 50 μl was naso-, maxillo-, and ethmoid turbinate in 27-week-old rats. In this case, the volume was enough to spread to the ethmoid turbinate. Differences in the exposed area might be caused by differences in the volume of the nasal cavity. It was also indicated that the main exposed area was the inferior meatus in the 30 min immediately after administration. At all administration volumes, however, notice should be taken of the outflow of nasal drops into the oral cavity through the nasopalatine.<br>

Journal

  • Experimental Animals

    Experimental Animals 45 (1), 15-22, 1996

    Japanese Association for Laboratory Animal Science

Citations (3)*help

See more

References(36)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top