Stabilizing Effects of Adenosine on the Membrane Currents and Tension Components of the Bullfrog Atrium
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- GOTO Masayosi
- Department of Physiology, Faculty of Medicine, Kyushu University
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- YATANI Atsuko
- Department of Physiology, Faculty of Medicine, Kyushu University
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- TSUDA Yasuo
- Department of Physiology, Faculty of Medicine, Kyushu University
Bibliographic Information
- Other Title
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- Stabilizing Effects of Adenosine on the
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Description
The effects of exogenously applied adenosine on the membrane potentials, currents and tension components of the bullfrog atrium were analysed under voltage clamped and unclamped conditions with the double sucrose-gap method.<BR>Adenosine above 10-3 M produced a prolongation of action potential accompanied by a slight augmentation of contraction which was followed by a sustained depression. The recovery was slow. Under voltage clamp conditions, adenosine merely produced a negative inotropic effect depressing ICa-dependent and -independent tensions. In the membrane currents, INaf, Is(ITa), Ix and background current (Ib) were all depressed. In the presence of adrenaline, the increased Is, Ix and contraction were inhibited by adenosine in a lower dose (10-5-10-3 M), and the inhibition of Is and ICa-dependent tension were more prominent in the presence of than in the absence of adrenaline. Under the effect of ATP, which has a catecholamine-like action, similar selective inhibitions were observed. It was concluded that adenosine has a sustained stabilizing action on the myocardium to survive, especially in the presence of adrenaline, by depressing the augmented ICa and contraction.
Journal
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 28 (5), 611-625, 1978
THE PHYSIOLOGICAL SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680018721152
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- NII Article ID
- 130003404150
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- NII Book ID
- AA00691224
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- COI
- 1:CAS:528:DyaE1MXhtlegu7g%3D
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- ISSN
- 18811396
- 0021521X
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- NDL BIB ID
- 2072580
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- PubMed
- 310904
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed