Effects of Removal of Na〔+〕 and Cl〔-〕 on Spontaneous Electrical Activity, Slow Wave, in the Circular Muscle of the Guinea-Pig Gastric Antrum
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- Tomita Tadao
- Institute for Comprehensive Medical Science, Fujita Health University
書誌事項
- タイトル別名
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- Effects of Removal of Na+ and Cl- on Spontaneous Electrical Activity, Slow Wave, in the Circular Muscle of the Guinea-Pig Gastric Antrum.
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In the circular muscle of the guinea-pig gastric antrum, a decrease in the external Na+ to less than 20 mM produced depolarization of the membrane with transient prolongation of the slow wave. This was followed by a high rhythmic activity. The activity was inhibited by reapplication of Na+ before recovery. The depolarization in Na+-deficient solution was prevented and rhythmic activity continued at about 5/min for at least 6 min by simultaneous removal of K+, Ca2+, or Cl−. After exposure to a Na+- and Cl−-deficient solution for a few minutes, reapplication of the Na+ in Cl−-deficient solution inhibited generation of the slow wave until Cl− reapplication. Similar results were obtained when Na+ and Cl− were reapplied in the absence of K+ after exposure to a Na+-, K+-free , and Cl−-deficient solution, although the inhibition was weaker than Na+ reapplication in a Cl−-deficient solution. In the presence of furosemide or bumetanide, a strong inhibition of activity was produced by the reapplication of Na+ and Cl− after exposure to an Na+- and Cl−-deficient solution. A hypothesis is presented that intracellular Ca2+ concentration ([Ca2+]i) is the most important factor determining the generation and frequency of the slow wave and that [Ca2+]i is regulated by the Na+ concentration gradient across the plasma membrane. The recovery of the Na+ concentration gradient by Na+ reapplication after removal of Na+ and Cl− is mainly controlled by a Na+-K+-Cl− co-transport.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 50 (5), 469-477, 2000
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680019190144
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- NII論文ID
- 130004435735
- 10008291992
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD3cXptVaqu7c%3D
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- ISSN
- 18811396
- 0021521X
- http://id.crossref.org/issn/0021521X
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- NDL書誌ID
- 5591196
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- PubMed
- 11120913
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可