Biphasic Hypothermia in Mice Infected with a Parasitic Nematode, Trichinella spiralis.
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- NISHINA Masami
- Departments of Medical Zoology, Saitama Medical School
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- SUZUKI Masahiko
- Department of Pharmacology, Saitama Medical School
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In BALB/c mice infected with Trichinella spiralis, changes in body temperature (Tb) were observed over 35 days after the infection. T. spiralis infection induced hypothermia two times at 7 and 28 days after infection. The initial decrease persisted for about one week with a peak (37.1±0.62°C) around 10 days after the infection, while the later phase persisted for at least one week. Both 10 and 35 days after the infection, there were remarkable decreases in Tb. The serum glucose level of infected mice at 10 days was significantly (p<0.01) decreased compared with that of control mice at the same number of days, while the level in infected mice at 35 days was not decreased. Moreover, the later phase of hypothermia was prevented by the cyclooxygenase inhibitor indomethacin (10 mg/kg i.p.), while the initial phase was not. We conclude that hypothermia was caused by two different mechanisms, involving the effects of hypoglycemia and prostaglandins.
収録刊行物
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- Experimental Animals
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Experimental Animals 51 (2), 207-211, 2002
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390282680019589760
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- NII論文ID
- 10008394440
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 6136446
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- PubMed
- 12012735
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可