Dynamic analysis of secretagogue-induced amylase secretion from rat pancreatic acini studied by perifusion system.
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- 今村 浩一郎
- The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- 若杉 英之
- The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- 篠崎 博嗣
- The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- 井林 博
- The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
書誌事項
- タイトル別名
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- Dynamic Analysis of Secretagogue induce
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抄録
A perifusion system was applied for the study on stimulus-enzyme secretion coupling in dispersed pancreatic acini. The system is highly simple, preserves the acini up to more than 3hr, and makes feasible clear-cut examination on the time course of enzyme secretion caused by secretagogues.<br>Caerulein (10-9M) and carbamylcholine (10-5M) caused a biphasic amylase secretory pattern consisting of an initial burst secretion and a sustained one. Caerulein induced a persistent amylase release even after cessation of the stimulation, while carbamylcholine-stimulated amylase release returned to basal levels. Atropine inhibited completely carbamylcholine-stimulated amylase release and the successive stimulation by caerulein evoked the amylase secretion with a decreased initial burst secretion. In calcium free medium, caerulein and carbamylcholine induced only a slight secretion, particularly in the sustained secretion phase and a gradual increase occurred with the addition of calcium.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 33 (5), 687-698, 1983
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680019669760
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- NII論文ID
- 130003404212
- 40005307879
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DyaL2cXjtVansg%3D%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 2620821
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- PubMed
- 6199537
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可