Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

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  • LEE Hyeon Yong
    School of Biotechnology and Bioengineering, Kangwon National University
  • HWANG In Koo
    Department of Anatomy, College of Medicine, Hallym University
  • KIM Dae Ho
    School of Biotechnology and Bioengineering, Kangwon National University
  • KIM Jung Hwa
    School of Biotechnology and Bioengineering, Kangwon National University
  • KIM Chang Ho
    School of Biotechnology and Bioengineering, Kangwon National University
  • LIM Beong Ou
    Department of Applied Biochemistry, Konkuk University
  • KANG Tae-Cheon
    Department of Anatomy, College of Medicine, Hallym University
  • BANG Kyung Hwan
    National Institute of Crop Science
  • SEONG Nak Sul
    National Institute of Crop Science
  • LEE Hak Ju
    Forest Research Institute
  • KIM Jong Dai
    School of Biotechnology and Bioengineering, Kangwon National University
  • WON Moo Ho
    Department of Anatomy, College of Medicine, Hallym University

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Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 54 (1), 21-27, 2005

    公益社団法人 日本実験動物学会

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