Effects of Naloxone on Respiratory Sensation before and after a Removal of Severe Respiratory Stress
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- Nishino Takashi
- Department of Anesthesiology, Graduate School of Medicine, Chiba University
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- Isono Shiroh
- Department of Anesthesiology, Graduate School of Medicine, Chiba University
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- Shinozuka Norihiro
- Department of Anesthesiology, Graduate School of Medicine, Chiba University
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- Ishikawa Teruhiko
- Department of Anesthesiology, Graduate School of Medicine, Chiba University
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Severe respiratory stress causes dyspnea, and a sudden release of this stress frequently accompanies a euphoric sensation. We hypothesized that acute severe respiratory stress may result in an elaboration of endogenous opioids within the central nervous system, and that these opioids may play significant roles in relieving dyspnea and generating euphoric sensation after a sudden removal of the stress. To test this hypothesis, we examined the effects of naloxone (0.04 mg/kg, I.V.) and the placebo (normal saline) on changes in respiratory sensation before and after the release of severe respiratory stress in a double-blind, randomized, crossover study in 14 healthy adults. Acute severe respiratory stress was induced by loaded breathing with a combination of resistive loading and hypercapnia. The subjects rated their changes in sensation by using a bidirectional visual analogue scale. Naloxone pretreatment affected neither the ventilation nor the development of dyspneic sensation during loaded breathing. Naloxone pretreatment only slightly attentuated the euphoric sensation developed after the release of severe respiratory stress. These findings suggest a small role of opioids in relieving dyspnea and in generating euphoria before and after a sudden removal of stress.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 55 (2), 117-126, 2005
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680020205184
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- NII論文ID
- 10016627385
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- NII書誌ID
- AA00691224
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 7362149
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- PubMed
- 15888211
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可