Estimation of Baroreflex Gain Using a Baroreflex Equilibrium Diagram.

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Two types of closed-loop perturbations can be applied to the arterial baroreflex system. The first (PD1) is introduced into the baroreceptors without a direct effect on arterial pressure (AP), whereas the second (PD2) initially affects AP. Neck suction and hemorrhage are examples of PD1 and PD2, respectively. To estimate the baroreflex open-loop gain (GBaro) without knowing the absolute magnitudes of PD1 and PD2, we explored a new strategy to estimate GBaro by combining PD1 and PD2 in a baroreflex equilibrium diagram. In this diagram, the neural arc presents the input-output relationship between baroreceptor pressure input and sympathetic nerve activity (SNA). The peripheral arc presents the input-output relationship between SNA and AP. In 8 anesthetized rabbits, we estimated GBaro by multiplying the slopes of the peripheral arc determined from PD1 and the neural arc determined from PD2. We also estimated GBaro by a conventional open-loop analysis. The GBaro values estimated by the equilibrium diagram and the open-loop analysis showed a positive correlation (y = 0.80x + 0.22, r2 = 0.95) and a standard error of estimate of 0.21 across the animals. We conclude that GBaro was estimated well by combining PD1 and PD2 in the equilibrium diagram.<br>

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