Estimate of Aztreonam (AZT) Hydrolyzing Enzymes from Clinically Isolated AZT-Resistant Gram-Negative Bacilli

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  • KOUDA Masakazu
    Central Clnical Laboratories, Tokyo Metropolitan Police Hospital
  • KUMAGAI Ikuko
    Central Clnical Laboratories, Tokyo Metropolitan Police Hospital
  • KOBAYASHI Jun-ichi
    Central Clnical Laboratories, Tokyo Metropolitan Police Hospital
  • SUGAI Ryoko
    Central Clnical Laboratories, Tokyo Metropolitan Police Hospital
  • MATSUZAKI Hiroko
    Central Clnical Laboratories, Tokyo Metropolitan Police Hospital
  • NAKAYA Rintaro
    Department of Microbiology, Tokyo Medical and Dental University, School of Medicine

Bibliographic Information

Other Title
  • 臨床分離グラム陰性桿菌に見られるAztreonam (AZT) 耐性菌とAZT不活化酵素の型の推測
  • リンショウ ブンリ グラム インセイ カンキン ニ ミラレル Aztreona

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Description

The MICs of Aztreonam (AZT) against 590 clinical isolates of Gram-negative bacilli were determined. About 13.4%(79 strains) of the isolates were AZT-resistant (MIC; 12.5μg/mAl≤.).<BR>The resistance pattern against various β-lactams and the effects on MICs of combination of Clavulanic acid (CVA) and AZT against AZT resistant strains suggested that AZT was inactivated by either type of IV (K1), Va (OXA1), or PSE2 β-lactamases.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 64 (10), 1345-1354, 1990

    The Japanese Association for Infectious Diseases

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